Argentina remain undefeated for 28 matches as the visitors beat hosts Chile by 2-1 margin.
Goals from Angel Di Maria and Lautaro Martinez gave the Lionel Scaloni’s boys the three points without Lionel Messi.
Argentina opted to rest Messi after his COVID-19 infection but his Paris Saint Germain teammate Di Maria stepped up to give the visitors the lead with a trademark curling shot from outside the box after 10 minutes.
Chile's English-born striker Ben Brereton equalised just over 10 minutes later when he sent a fine looping header over goalkeeper Emiliano Martinez.
Argentina then took advantage of an injury to Chile goalkeeper Claudio Bravo to seal the win 11 minutes before halftime.
Bravo was preparing to be substituted when Rodrigo de Paul fired in a fierce drive from 30 metres, and with the goalkeeper only able to parry the shot Lautaro Martinez followed up to slot home the rebound.
The result was a huge blow to Chile's hopes of qualifying for Qatar. They are seventh, on 16 points, in the 10-team South American qualifying group with only three matches to play.
Meanwhile, Brazil had to settle for a 1-1 draw at Ecuador in a remarkable World Cup qualifier on Thursday after Felix Torres' header 15 minutes from time canceled out an early Casemiro strike.
The incident-packed clash saw both sides have a player sent off inside the first 20 minutes and Brazil goalkeeper Alisson shown a red card on two occasions only for both to be rescinded after consultation with the Video Assistant referee (VAR).
Brazil's Eder Militao in action with Ecuador's Enner Valencia.
Ecuador had a goal chalked off and two penalty awards rescinded via VAR, including one in second-half stoppage time.
Casemiro had put Brazil ahead after five minutes when he hammered home from close range after a goalmouth scramble.
Ecuador goalkeeper Alexander Dominguez was red-carded after 15 minutes for a reckless challenge, and Brazil fullback Emerson Royal was dismissed five minutes later for a second yellow card following a clumsy tackle.
