Pakistan's Prime Minister Imran Khan has been ousted from power after losing a no-confidence vote in his leadership, reports BBC.
The vote was held past midnight after opposition parties brought a motion against him, which was upheld by the Supreme Court.
Mr Khan had said he would not recognise an opposition government, claiming - without evidence - that there was a US-led conspiracy to remove him.
The assembly will now appoint a new prime minister.
That person will be able to hold power until October 2023 when the next election is due to be held.
Mr Khan becomes the first Pakistani prime minister to be ousted by a no-confidence vote.
The Supreme Court ruled on Thursday that Mr Khan, 69, had acted unconstitutionally when he blocked the no-confidence vote and dissolved parliament.
This made several opposition members furious, with some accusing the prime minister of treason.
Minutes before the vote started, the speaker of Pakistan's lower house of parliament - an ally of Mr Khan - announced his resignation. Members of Mr Khan's party left the building, insisting he was the victim of an international conspiracy.
Opposition parties were able to secure 174 votes in the 342-member house in support of the no-confidence motion, the house speaker said, making it a majority vote.
The former captain of Pakistan's national cricket team was elected prime minister in 2018, and promised to fight corruption and fix the economy.
But those pledges have gone unmet with the country gripped by a financial crisis.
In late March a series of defections deprived him of his majority and left him fighting for his political career.
The BBC's Secunder Kermani says Mr Khan is widely regarded as having come to power with the help of Pakistan's army, but now observers say they have fallen out.
Mr Khan has repeatedly said that Pakistan's opposition parties are working with foreign powers. He also claims that he is the target of a US-led conspiracy to remove him because of his refusal to stand with Washington on issues against Russia and China.
The US has said there "no truth" in these allegations, and Mr Khan has never provided any evidence.
He visited Moscow to meet President Vladimir Putin as Russia was launching the invasion of Ukraine and has previously criticised what the Bush administration called the war on terror.
