Champions League holders Real Madrid will play local rivals Atletico Madrid in the last 16 of the competition Liverpool will take on Paris Saint-Germain after the teams were paired together in Friday`s draw.
Real thrashed Premier League champions Manchester City 6-3 on aggregate in the playoffs and will now make the trip across town to play Atletico, the side they beat in the 2014 and 2016 finals, reports The Daily Star.
Liverpool finished first in the 36-team league phase of the competition to qualify directly for this stage, while PSG had to come through a two-legged play-off tie in which they crushed fellow French side Brest 10-0 on aggregate.
The first leg will take place at the Parc des Princes in Paris on March 4 or 5, with the return at Anfield a week later.
The clubs last met in the Champions League in the group stage in 2018/19, when PSG won 2-1 at home after Liverpool triumphed 3-2 in England.
Bayern Munich will take on German rivals Bayer Leverkusen, while Arsenal face PSV Eindhoven and Inter Milan take on Feyenoord, who are fresh from knocking out AC Milan in the play-offs.
Barcelona will face Benfica, who they defeated 5-4 away in Lisbon in the league phase last month.
Aston Villa will face Club Brugge, having already lost away to the Belgians in the league phase.
Last season`s beaten finalists Borussia Dortmund will take on French side Lille.